心理智能测验检测原发性肝癌并肝硬化患者并发亚临床肝性脑病的研究

Study of subclinical hepatic encephalopathy in hepatic cellular carcinoma patients accompanying cirrhosis by psychometric tests

用心理智能测验的方法研究原发性肝癌合并肝硬化患者并发亚临床肝性脑病 (SHE)的情况。方法 用数字连接试验 (NCT)、数字符号试验 (DSy)和数字广度试验 (DSp) 3种心理智能测验对 81例原发性肝癌并肝硬化患者及 5 0例对照进行检测。结果 两组的各检测值存在明显差异 ,81例患者中检出NCT、DSy和DSp异常例数分别为 16(19.8% )、12 (14.8% )和 10 (12 .3 % ) ,共检出亚临床肝性脑病 2 0例 (2 4.7% )。肝功能ChildB级组亚临床肝性脑病的发生率明显高于ChildA级组。结论 原发性肝癌并肝硬化患者中有一定的亚临床性脑病发生率 。

Objective To study the subclinical hepatic encephalopathy (SHE) in hepatic cellular carcinoma patients accompanying cirrhosis through psychometric tests. Methods 81 patients with hepatic cellular carcinoma accompanying cirrhosis and 50 controls were detected with number connection test (NCT), digital span test (DSp) and digital symbol test(DSy).Results The abnormal rate of NCT、 DSy and DSp in patients was 19.8%(16/81)、14.8%(12/81) and 12.3%(10/81) respectively. The patients of Child B group had a significant higher abnormal rate than Child A group. Conclusion SHE had a incidence rate of 24.7% in hepatic cellular carcinoma patients accompanying cirrhosis in this research, its occurrence was associated with the impairment degree of liver function.