老年人瑞米芬太尼静脉维持麻醉

INTRAVENOUS REMIFENTANIL ANESTHESIA IN ELDERLY PATIENTS

目的 探索老年人全身麻醉时瑞米芬太尼的维持用量。方法 在１００例老年手术病人全身麻醉中，采用异丙酚ＴＣＩ或地氟醚吸入加瑞米芬太尼静脉维持。按年龄和麻醉选择分组，观察各组瑞米芬太尼维持用量。结果 Ａ组（６５～７４岁）和Ｂ组（７５岁以上）的瑞米芬太尼维持量分别为０．１８μｇ·ｋｇ－１·ｍｉｎ－１和０．１５μｇ·ｋｇ－１·ｍｉｎ－１。结论 老年人全身麻醉时，瑞米芬太尼用量较年轻者减少。瑞米芬太尼镇痛作用强，体内消除快，代谢不受肝肾功能影响，适用于老年麻醉。

Objective This study aimed to find the dose of remifentanil for maintenance of general anesthesia in elderly. Methods A total of 100 patients aged over 65 years were selected undergoing general anesthesia. According to age and anesthetic drugs used, patients were diveded into four groups and their doses of remifentanil were observed respectively during the period of anesthesia. Results The dose of remifentanil in the Group A (age of 65 to 74 years) and Group B (age over 75 years) were 0. 18 μg· kg-1· min - 1 and 0. 15μg· kg-1· min-1 respectively. Conclusions in general anesthesia, the dose of rendfentanil for elderly patients was less than for younger ones. Because of its strong effect and rapid elimination, rendfentanil is a good analgesic for general anesthesia in elderly.