肾综合征出血热血浆神经肽Y水平及临床意义(附104例报告)

Study of Plasma Neuropeptide Y Level in Patients with Haemorrhagic Fever with Rend Syndrome

采用放免分析法检测肾综合征出血热 ( HFRS)患者血浆神经肽 Y( NPY)含量。发现 HFRS患者血浆 NPY浓度 ( 88.92± 2 9.78pg/ ml)较正常人组水平 ( 36.19± 9.0 7pg/ ml)显著增加 ( P<0 .0 1)。NPY变化规律为从发热期即见升高 ,少尿期达高峰 ,多尿期逐渐下降 ,随着病情的缓解及肾功能的恢复逐渐正常。认为 HFRS病程中 NPY血浆浓度变化与病情一致 ,其可能在 HFRS某些发病环节中起作用 ;检测血浆 NPY水平可作为 HFRS的病情监测指标 ,对判断预后及揭示

Determining the levels of neuropeptide Y(NPY)in patients with haemorrhagic fever with renal syndrome(HFRS)by radioimmunoassay,we found average level of plasma NPY in patients with HFRS was 88 92±29 78pg/ml,(it was 36 19±9 07pg/ml in healthy people) There was significant difference between them(P<0 01) The law of NPY increasing was that it began to increase in fever period,and it increased to the highest top in oliguria period,then it began to decrease from diuresis period, it returned to normal following the recovery of renal function Their changes were relative with the severe degree of HFRS,so we think that NPY maybe perform catain affect in some links of coming on HFRS Checking the level of plasma NPY may be regarded a index of determining development and its prognosis It′s important in studing some of pathogenesis of HFRS