乙型肝炎病毒相关性肾炎的临床与病理

Clinical and pathological study on hepatitis B virus associated nephritis

目的探讨乙型肝炎病毒（ＨＢ Ｖ）与肾小球病变的关系以及乙肝病毒相关性肾炎的发病机理。方法对 ２０例血清 ＨＢＳＡｇ阳性临床表现为肾病综合征的患者肾穿刺标本行光镜及电镜检查．结果 １４ 例 肾穿刺标本行免疫荧光检查 ＨＢＳＡｇ 颗粒状沉积在毛细血管襻及系膜区，其中 １２例为膜性肾病，２例为微小病变型骨炎。结论乙型肝炎病毒感染可引起乙肝病毒相关性肾炎，其病理主要表现为膜性肾病。

Objective To study the relationship between hepatitis B virus (HBV) infection and glomerular lesion and the pathogenesis of HBV associated nephritis. Methods Renal biopsy specimens from 20 patients with nephrotic syndrome and positive serum HBsAg were examined with light and eletronic microscopy. Results Granular depostion of HBsAg in the capillary loops and mesangium were found in specmens from 14 patients with immunofluorescent examination, among which 12 were dignosised as membranous nephropathy, and 2. minimal change disease. Conclusion Hepatitis B virus infection can causes HBV associated glomerulonephritis, and the majority of these cases present as membranous nephropathy.