^(125)碘放射性粒子植入内放疗治疗肿瘤及对肿瘤坏死因子的影响研究

Studies of the Effects of Iodine 125 Radioactive Particles within the Implant Radiation Therapy for Cancer and Tumor Necrosis Factor Influence

目的:评价125碘放射性粒子植入内放疗治疗肿瘤的临床效果及其对肿瘤坏死因子的影响。方法:选取70例患者并随机分为两组,40例患者采用常规外放疗作为对照组,30例患者在对照组基础上采用碘125放射性粒子植入内放疗,治疗前后测定两组患者TNF并进行比较,同时观察比较两组患者治疗效果。结果:观察组肿瘤控制率为88.57%,对照组为80.00%,两组差异显著(P<0.05)。两组患者治疗前TNF无显著差异,治疗后观察组TNF为(1.789±0.530)g/L,对照组患者为(1.725±0.487)g/L,观察组高于对照组,但差异不显著。结论:125碘放射性粒子植入内放疗治疗肿瘤疗效显著,可明显提高肿瘤局部控制率,且TNF升高水平与外放疗基本相似,安全可行。

Objective：To evaluate the radioactive iodine 125 implanted in the clinical effect of radiation therapy for cancer and the tumor necrosis factor influence.Methods：The 70 patients and randomly divided into two groups,30 cases were treated by the conventional radiotherapy as control group,30 patients in the control group on the basis of radioactive iodine 125 implanted in radiation therapy,two groups of patients was before and after treatment and TNF comparison,and observe compared between the two groups treatment effect.Results：The observation group tumor control rates to 88.57%,to 80.00% in the placebo group,the two groups（P〈0.05）.Two groups of patients with no significant differences between treatment TNF before and after treatment,the observation group TNF fo（1.789±0.530） g/L,patients for（1.725±0.487） g/L,the observation group higher than those in the control group,but the difference was not significant.Conclusion：125 radioactive iodine implanted in radiation therapy tumor curative effect is distinct,can obviously improve the tumor local control,and rise to the level of TNF radiation basic similar,safe and feasible.