胰岛素强化治疗老年脓毒症临床分析

The Clinical Analysis on Insulin Used for Intensive Cure of Older Patients with Sepsis

目的:探讨胰岛素强化治疗老年脓毒症的临床效果。方法:74例老年脓毒症患者随机分为实验组和对照组,两组均给予支持治疗以及对症治疗。此外,根据血糖控制值[对照组:(10.0～11.1)mmol/L;实验组:(4.4～8.3)mmol/L],两组分别给予胰岛素泵注治疗。结果:两组均未发生严重的相关并发症,血糖达标率无显著性差异(p>0.05),实验组一周后CRP值,新增感染率,机械通气率和病死率均显著低于对照组(t=17.865,P<0.01;χ2=4.255,P<0.01;χ2=4.038,P<0.01;χ2=5.240,P<0.01)。结论:胰岛素强化治疗脓毒症,可以将血糖控制在相当较低水平,对于改善病情有重要意义,值得临床进一步研究。

Objective：To explore the clinical effect of insulin used for intensive cure of older patients with sepsis.Methods：74 cases of f older patients with sepsis as studied object were randomly divided into experimental group and control group.Both of groups were given symptomatic treatment and supporting therapy,besides,two groups were given insulin respectively according to control indexes of FBG [control group：（10.0～11.1）mmol/L：experimental group：（4.4～8.3]mmol/L].Results：There was no serious side-reactions happened of two groups,and reached rate of FBG between two groups had no significant difference（P〉0.05）.The CRP after one year,new infectious ra te（t=17.865,P〈0.01;χ2=4.255,P〈0.01;χ2=4.038,P〈0.01;χ2=5.240,P〈0.01）.Conclusion：Insulin used for intensive cure of older patients with sepsis,can control GBG to relatively low level and prompt the disease turning better,so it deserved study in clinical work further.