高血压病患者血、尿β_2微球蛋白、白蛋白浓度变化及其临床意义

The Clinical Implication of Serum,Urine β_2-Microglobulin and Albumin Level in Patients with Hypertension

目的:探讨高血压病患者肾脏损伤状态。方法:采用RIA测定了80例正常人和130例高血压患者血、尿β2-微球蛋白(β2-m)、尿白蛋白(ALb)微量蛋白质的含量变化。结果:高血压组血、尿β2-m、ALb均较正常对照组增高显著(P<0.01),其增高幅度与高血压病情密切相关。结论:血、尿微量β2-m、尿ALb测定是监测高血压病肾功能损害的灵敏指标,而且对肾单位损害部位具有定位作用,对高血压病肾脏损害的早期诊断、治疗和高血压分级有重要意义。

Objective：To investigate the status of hypertension in patients with kidney damage.Methods：Using RIA in 80 normal sensitive indicators,monitoring of renal damage in hypertension and nephron lesion has a role in positioning hypertension kidney damage early diagnosis,treatment and hypertension points level has important significance.subjects and 130 patients with hypertension blood,urine β2-microglobulin（β2-m）,and urine of albumin（ALb） trace protein content changes.Results：the hypertension group Blood,urine β2-m,ALb compared with the normal control group increased significantly（P〈0.01）,is closely related to its increased amplitude and hypertension condition.Conclusion：blood,urine micro β2-m,the urine ALb measured Sensitive indicators, monitoring of renal damage in hypertension and nephron lesion has a role in positioning hypertension kidney damage early diagnosis,treatment and hypertension points level has important significance.