血清脑型利钠肽与急性脑梗死病情及预后的关系研究

Study on the Relationship between Serum BNP and Prognosis of Patients with Acute Cerebral Infarction

目的探讨血清脑型利钠肽（BNP）水平与急性脑梗死（ACI）病情及预后的关系。方法对122例病程两周内的ACI患者在入院时进行血清BNP水平测定，根据BNP水平，将患者分为：A组（BNP〈300pg／ml）；B组（BNP300～900pg／ml）；C组（BNP〉900pg／ml）。应用关国国立卫生研究院卒中量表（NIHSS）及BarthelIndex（BI）分别对患者入院时及治疗三个月后进行评分，并将BNP水平与NIHSS及m评分进行相关性分析。结果患者血清BNP水平与入院时及治疗三个月后的NIHSS呈显著正相关（P〈O．05），与BI评分呈显著负相关（P〈O．05）。结论急性脑梗死发病后两周内的血清BNP水平可以用于对患者的病情及预后评估。

Objective To explore the relationship between prognosis and the levels of serum brain natriuretic peptide （BNP） in acute cerebral infarction （ACI） patients. Methods The serum BNP levels of 122 patients with ACI no more than 2 weeks were examined on admission. According to the levels of serum BNP,these patients were divided into three different groups, A group （BNP〈300 pg/ml） ,B group （BNP 300-900 pg/ml） and C group （BNP〉900 pg/ml）. All the patients were ex- amined with National Institutes of Health Stroke Scale （NIHSS） and Barthel Index （BI） scores on admission and three months after admission. And then,analyses the relationship between NIHSS and BI scores and the levels of serum BNP. Resuits The levels of serum BNP examined were positive correlated with NIHSS scores （P〈0.05）. There were negative cor- related between the levels of serum brain BNP and BI scores （P〈0.05）. Conclusion The levels of serum BNP within 2 weeks after symptom onset might be useful for evaluating patient＇s condition and prognosis.