糖尿病乳酸酸中毒患者检测同型半胱氨酸的意义

Significance on Analysis Homocysteine in Diabetic Lactate Acidosis

目的研究糖尿病乳酸酸中毒患者检测同型半胱氨酸的意义。方法选取100例T2DM患者，其中60例服用双胍类降糖药物，另择100例健康人作为对照组。血气动脉血检测两组的血乳酸（Lac），透射比浊法检测糖化血红蛋白（HbAlc），酶法检测肌酐（Cr）、尿素氮（BUN）和同型半胱氨酸（Hcy），数据进行相关的统计学分析。结果服用双胍类降糖药物的糖尿病患者乳酸水平比未服用此类药物的患者明显升高，两者差异有统计学意义（t=12．374，P〈0．01）；服用双胍类降糖药物的糖尿病患者与未服用双胍类降糖药物的患者，以及对照组的Cr，BUN和Hcy值比较差异有统计学意义（P〈O．01）；未服用双胍类降糖药物的患者（B组）Hcy值和对照组比较无显著性差异（t=0．648，P〉0．05）。结论高同型半胱氨酸血症是糖尿病乳酸酸中毒的一个重要危险因素。

Objective Significance on analysis homocysteine in Diabetic lactate acidosis. Methods Choiced 60 patients with DM administered Metformin and 100 cases as control group. The lactic acid of artery blood was detected by blood gas analy- sis. HbAlc,Hcy,BUN and Cr were detected by the standard method. Results Patients with administered Metformin had higher level of lactate than those with no administered Metformin （t= 12. 374, P〈0.01）. The difference of Hcy, BUN and Cr was significant among patients with or no administered Metformin and control group （P〈0. 01）, and Hcy has no differ- ence between no administered Metformin and control group （ t=0. 648, P〉0. 05）. Conclusion Hcy was an independent risk factor in Diabetic lactate acidosis.