急性白血病患者血清VEGF，IL-8和TF检测的临床意义

Clinical Significance of Detection of Serum VEGF, IL-8 and TF in Patients with Acute Leukemia

目的探讨血管内皮生长因子、白细胞介素8和组织因子在急性白血病患者病情进展、疗效观察及预后判断中的意义。方法用酶联免疫吸附方法测定85例急性白血病患者和28例健康体检者血清血管内皮生长因子、白细胞介素8和组织因子的含量。结果初发未治组患者血清血管内皮生长因子（439．2土196．3）pg／ml、白细胞介素8（73．6±31．7）pg／ml和组织因子（10．8±5．3）pg／ml含量显著高于完全缓解组和正常对照组（P〈0．05）。完全缓解组患者血清血管内皮生长因子（123．4±68．1）pg／ml、白细胞介素8（14．5±4．8）pg／ml和组织因子（5．1±3．2）pg／ml含量显著低于未缓解组和复发组（P〈O．05）。未缓解组、复发组患者血清血管内皮生长因子、白细胞介素8和组织因子含量高于初发未治组，但差异无统计学显著性意义（P〉O．05）。结论血管内皮生长因子、白细胞介素8和组织因子是判断急性白血病患者病情进展、疗效观察及预后的重要指标。

Objective To explore the significance of vascular endothelial growth faetor（VEGF） ,interleukin-8（IL-8） and tissue factor （TF） in evaluation of development,curative effect and prognosis of acute leukemia（AL） patients. Methods ELISA was used to detect the serum levels of VEGF,IL-8 and TF of 85 AL patients and 28 healthy individuals. Results The serum levels of VEGF （439.2±196.3） pg/ml, IL-8 （73.6± 31.7） pg/ml and TF （10. 8±5.3） pg/ml of new diagnoses groug were significantly higher than those of complete remission group and control group（P〈0.05）. The serum levels of VEGF（123.4 ±68.1）pg/ml,IL-8（14.5±4. 8） pg/ml and TF （5.1 ±3.2） pg/ml of complete remission group were significantly lower than those of non-remission group and recurring group （P〈0. 05）. The serum levels of VEGF, IL-8 and TF of non-remis- sion group, recurring group were higher than those of new diagnoses groug, but there were not significantly different（ P〉 0.05）. Conclusion It is concluded that the serum levels of VEGF, IL-8 and TF could be used as the indicators for under- standing clinical features,evaluating disease status and predicting prognosis in AL patients.