亚低温对重型颅脑损伤患者血清CRP影响的研究

Effects of mild hypothermia on serum CRP in patients with severe brian injury

目的:研究亚低温对重型颅脑损伤(STBI)患者血清C-反应蛋白(CRP)水平的影响。方法:选取STBI患者49例分为A、B两组。B组给予常规治疗,A组另予亚低温治疗3～5d。共检测7次血清CRP,治疗前行格拉斯哥昏迷评分(GCS),出院后3个月行格拉斯哥预后评分(GOS)。对GCS、GOS和CRP值行统计学分析。结果:两组入院时GCS、血清CRP值差异无统计学意义(P>0.05)。A组血清CRP值第3d达到峰值,B组第4d达到峰值。从第3d开始,两组血清CRP值差异有统计学意义(P<0.05)。出院后3个月两组GOS差异有统计学意义(P<0.05)。结论:亚低温能够使STBI患者血清CRP峰值提前到达,而且下降更快;亚低温作为一种脑保护治疗方法,能够有效减轻脑水肿,对STBI有较好的脑保护作用。

Objective：To study the effects of mild hypothermia on serum CRP in patients with severe brian injury. Methods：To select forty-nine patients with severe brian injury in experimental stage and divide into two groups： the trial group of Mild hypothermia （n=26） and the control group （n=23）. The control group was gived conventional treatment, otherwise, the trail group was grived conventional treatment and mild hypothermia. All patients＇ serum CRP were detected seven times. Before treatment,get the GCS of every patient. Three months post-discharge, get GOS. Summary GCS and GOS scores and seven serum CRP values,then run statistical analysis.Results：The diversity between both groups＇GCS scores and serum CRP values is not significant on the origin of treatment （P〉0.05）. The trail group＇s serum CRP value achieve the peak on the thrid day, furthermore the control group chalk to the peak on the fourth day.The trail group＇s serum values is manifest lower than the control group on the thrid day （P〈0.05）. Moreover,it＇s GOS is obviously better than the control group （P〈0.05）. Conclusions： Mild hypothermia can make serum CRP＇s peak of the patients with severe brian injury reach in advance; Mild hypothermia have fine brain protection on severe brain injury.