摘要
目的通过实验研究陆英煎剂对小鼠的镇痛作用。方法镇痛实验采用小鼠热板法和醋酸扭体法,实验分为陆英煎剂组、盐酸曲马多组、生理盐水组,灌胃给药。结果与生理盐水组比较,陆英煎剂组和盐酸曲马多组对小鼠热板致痛的痛阈值均有不同程度的提高,对小鼠醋酸致痛引起的扭体次数均有明显的降低作用。结论陆英煎剂具有明显的镇痛作用,其镇痛作用比盐酸曲马多弱。
Objective To study the analgesic effect of Sambucus decoction on mice through an experiment. Methods Mice hot-plate method and method of mice writhing induced by acetic acid were adopted in the analgesic experiment. The subjects were divided into Sambucus decoction group, tramadol hydrochloride group, and saline group. They were delivered oral drug directly through stomach. Results Compared with the saline group, both Sambucus decoction group and tramadol hydrochloride had different degree of improvement in threshold of pain on Mouse hot-plate- induced pain. It showed obvious effect on reducing the number of mice writhing that caused by acetic acid-induced pain. Conclusion Sarnbucus decoction has obvious analgesic effect. Its analgesic effect is weaker than tramadol hydrochloride.
出处
《今日药学》
CAS
2012年第8期481-483,共3页
Pharmacy Today
关键词
陆英
盐酸曲马多
热板法
扭体法
镇痛作用
Sambucus
tramadol hydrochloride
hot plate
writhing method
analgesic effect
