氧化应激与支气管肺发育不良研究进展

Oxidative stress and bronchopulmonary dysplasia

支气管肺发育不良（ bronchopulmonary dysplasia, BPD）是早产儿重要疾病。BPD的病因及发病机制复杂，高浓度吸氧引起的BPD与机体氧化和抗氧化失衡有关。氧化应激与炎症反应过程关系密切，二者相互影响并在BPD的发生发展中起重要作用。活性氧作为第二信使调节大量与细胞增殖、凋亡和炎症反应相关的核转录因子活性，这可能是氧化应激从基因水平促进BPD发生发展的重要机制。目前BPD的防治仍处于探索阶段。该文探讨高浓度氧疗引起的氧化应激和炎症反应与BPD的内在联系及BPD的抗氧化防治措施。

Bronchopulmonary dysplasia（ BPD）, a serious disease in premature infant, obviously reduces the quality of life in the survivors. The etiological factors and pathological mechanism of BPD are very compli- cated. BPD caused by hyperoxia is associated with imbalance between the ability of antioxidation and the oxida- tion in body. There is a very close relationship between oxidative stress and inflammatory reaction, which influ- ence each other and play a critical role in the development of BPD. Reactive oxygen species as a second message regulate many nuclear factors related to the proliferation and apoptosis of cells, which probably are the important mechanisms that oxygen stresses promote the development of BPD from gene level. The intervention of preven- tion and treatment in BPD are still at the exploration stage. This paper summarizes the intrinsic link between oxi- dative stress induced by high concentration oxygen and BPD, and the prevention and treatment in BPD by anti- oxidant.