早期大剂量氨基酸在早产儿静脉营养中的研究进展

Current research of early high dose amino acids in parenteral nutrition of preterm infants

随着早产儿存活率的日益提高，其日后的营养状况逐渐被关注。特别是极低和超低出生体重儿，由于宫内营养不足，出生后对热卡需求高，单纯经胃肠道喂养往往不能满足其营养和代谢需求，静脉营养是其获取能量的重要方法。近年来，国外已普遍开展了静脉大剂量氨基酸的早期应用，并发现该方法不仅安全，而且对改善早产儿生长和营养状况是有效的。因此，生后迅速建立营养支持对追赶生长是十分必要的。

With the obvious increasing of the survival of preterm infants in recent years,more and more attention to nutritional status has been attracted. Due to intrauterine undemutrition, preterm infants are on the de- mand of high calorie after birth, especially the very low and extremely low birth weight infants. However, simple gastrointestinal feeding often cannot meet the demand of nutrition and metabolism in these infants. Therefore, parenteral nutrition is considered to be an important method to obtain energy. Recently, application of large dose of intravenous amino acids during the early postnatal period has been widely used in foreign countries. It has been demonstrated that implementation of this strategy is not only safe,but also helpful on the improvement of preterm infants growth and nutritional status. Thus, establishment of parenteral nutritional support rapidly after birth is very necessary for preterm infants to catch up with intrauterine growth rate.