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肾脏电压门控氯离子通道研究进展 被引量：2

Progress of renal voltage-gated chloride channel
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摘要 电压门控氯离子通道（voltage—gated chloride channel，C1C）是生物体内一类非常重要的氯离子通道，参与氯离子转运、细胞容量调节、细胞器酸化等病理生理过程，研究发现C1C-K与Dent病相关，CIC-5与Bartter综合征相关。该文就CIC的分类、结构、调控、在肾脏的分布及相关疾病作一综述。 Voltage-gated chloride channel（CIC） is a class of very important chloride ion channels in vi- vo, participating in the chloride ion transporter., cell volume regulation, cell control acidification and many patho- logical physiological process. The studies have found that C1C-K was related to dent disease,and CIC-5 was as- sociated with bartter syndrome. This article mainly reviews C1C-type chloride ion channel classification, struc- ture, regulation and distribution in the kidney, and summarizes the related diseases.
作者 赵金丽(综述) 崔岚巍(审校)
机构地区 哈尔滨医科大学附属第一医院儿科
出处 《国际儿科学杂志》 2012年第5期477-479,共3页 International Journal of Pediatrics
基金 黑龙江省科技计划项目（QC07C95） 黑龙江省教育厅科学技术研究项目（11531152） 黑龙江省博士后课题（LBH-Z08132）
关键词 电压门控氯离子通道 肾脏 Dent病 BARTTER综合征 Voltage-gated chloride channel Kidney Dent＇s disease Bartter＇s syndrome
分类号 R739.63 [医药卫生—肿瘤]
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参考文献24

  • 1郭晓强.ClC型氯离子通道[J].生理科学进展,2005,36(1):58-61. 被引量：9
  • 2Jentsch TJ, Stein V , Weinreich F ,et a1. Molecular structure and phys?iological function of chloride channels. Physiol Rev, 2002,82 (2) : 503-568.
  • 3Dutzler R, Campbell EB, Cadene M, et aI. Xvray structure of a CIC chloride channel at 3. 0 A reveals the molecular basis of anion selec?tivity. Nature ,2002,415 (6869) :287-294.
  • 4Estevez R, Schroeder BC, Accardi A, et aI. Conservation of chloride channel structure revealed by an inhibitor binding site in CIC-l. Neuron,2003 ,38( 1) :47-59.
  • 5Obermuller N, Gretz N, Kriz W, et a1. Swelling -activated chloride channel ClC-2, the chloride channel CIC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells. J Clin Invest, 1998 , 101 ( 3 ) : 635-642.
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二级参考文献10

  • 1Estevez R, Jentsch TJ. ClC chloride channels:correlating structure with function. Curr Opin Struct Biol, 2002, 12 :531 ～ 539.
  • 2Jentsch TJ, Stein V, Weinreich F,et al. Molecular structure and physiological function of chloride channels. Physiol Rev, 2002,82: 503 ～568.
  • 3Mindell JA,Maduke M, Miller C, et al. Projection structure of a ClC-type chloride channel at 6.5A resolution. Nature,2001,409: 219 ～ 223.
  • 4Dutzler R, Campbell EB, Cadene M, et al. X-ray structure of a ClC chloride channel at 3.0A reveals the molecular basis of anion selectivity. Nature, 2002,415: 287 ～294.
  • 5Estevez R, Schroeder BC, Accardi A,et al. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron,2003,38: 47 ～ 59.
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  • 7Dutzler R, Campbell EB, MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science,2003,300: 108～ 112.
  • 8Duffield M, Rychkov G, Bretag A, et al. Involvement of helices at the dimer interface in ClC-1 common gating. J Gen Physiol,2003,121: 149 ～ 161.
  • 9Iyer R, Iverson TM, Accardi A, et al. A biological role for prokaryotic ClC chloride channels. Nature,2002,419: 715～718.
  • 10Pusch M. Structural insights into chloride and proton-mediated gating of ClC chloride channels. Biochemistry, 2004,43: 1135 ～ 1144.

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国际儿科学杂志
2012年 第5期

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