摘要
早期肾脏发育过程中的尿路梗阻影响肾脏形态发生及生长,严重的将导致肾功能不全。15%~20%的梗阻性肾病患儿需要早期手术以维持肾功能,而部分没有显著肾功能下降的患儿有自然消退的趋势,可以行保守治疗。目前的影像学检查对于输尿管梗阻存在不确定性和有创性,因此寻找能反映。肾结构变化以及进行性。肾功能下降的尿生物标记物显得尤为重要。该文就各类关于肾功能的尿生物标记物,如转化生长因子-β1、单核细胞趋化蛋白-1、表皮生长因子、内皮缩血管肽-1等在输尿管梗阻的临床应用价值进行探讨,为临床诊断、防治输尿管梗阻以及肾脏不可逆损伤寻找新的途径提供重要理论依据。
Urinary tract obstruction that occurs during early kidney development affects renal morpho- genesis ,maturation and growth, and in the most severe cases this will ultimately cause renal insufficiency. 15% -20% of the patients with obstructive nephropathy require early surgical intervention to preserve renal function, another part of those children without significant loss of renal function may be appropriate in conserva- tive treatment because of spontaneous resolution. Current imaging examination for urethral obstruction are uncer- tainties and invasive, and therefore there is a need for urinary biomarkers that may be used as predictors for renal structural changes and decreasing renal function, and thereby provide the surgeon with more clear indications for surgical intervention. This review will discuss the clinical application value of various types of urinary biomark- ers, including transforming growth factor-β1, monocyte ehemoattractant protein-l, epidermal growth factor, endo- thelin-1, to provide important theoretical basis for searching new approaches for diagnosis, prevention and treat- ment of diseases related to ureteral obstruction and irreversible damage of kidney.
出处
《国际儿科学杂志》
2012年第5期484-487,共4页
International Journal of Pediatrics
关键词
输尿管梗阻
肾积水
生物标记物
儿童
Ureteral obstruction
Hydronephrosis
Biomarker
Children