胰岛素样生长因子结合蛋白7与肿瘤

Insulin-like growth factor binding protein 7 and tumors

胰岛素样生长因子结合蛋白7（insulin—like growth factor binding protein7，IGFBP7）通过与胰岛素样生长因子（insulin—like growth factor，IGF）、胰岛素相结合，延长IGF/胰岛素的半衰期，从而发挥IGF!胰岛素的生物学功能。与其他结合蛋白不同的是，IGFBP7能与胰岛素强有力的结合，从而能够不依赖IGF而发挥功能。IGFBP7在细胞生长、增殖和在肿瘤细胞的黏附、浸润、迁徙及肿瘤血管的形成等方面发挥作用，可能与某种信号传导通路有关。

Insulin-like growth factor binding protein 7 exert modulatory function in insulin-like growth factor/insulin（IGF/INS） protein network by carrying and transiting IGF/INS, or prolonging their half-life. IG- FBP7 has strong ability to bind insulin and low affinity to IGFs and plays a role in either IGFs-dependent way or IGFs-independent way. IGFBP7 involves in multiple function such as cell proliferation, adhesion, invasion, mi- gration and tumor vascular formation through several signaling pathways.