白血病抑制因子与中枢神经系统疾病研究进展

Leukemia inhibitory factor and central nervous system diseases

白血病抑制因子是一种多功能的细胞因子。近年来对白血病抑制因子在中枢神经系统中的作用研究取得了一些新进展。在多种中枢神经系统疾病及其动物模型中白血病抑制因子表达升高，其在中枢神经系统损伤病变中更多的是神经保护作用，被认为是一种神经营养因子。深入研究白血病抑制因子与中枢神经系统的作用，将为中枢神经系统疾病的治疗提供新策略。

Leukemia inhibitory factor（LIF） is a multifunctional cytokine. In recent years,investigations have made some advancement in the effect of LIF on central nervous system. LIF shows a high expression in various central nervous system diseases and related animal models, which shows a neuroprotective effect most time in central nervous system injuries. LIF is defined as a neurotrophic factor. It might provide a new strategy for the therapy of central nervous system diseases to undertake further studies on leukemia inhibitory factor and central nervous system diseases.