^13C-尿素呼气试验与儿童幽门螺杆菌感染及胃黏膜炎症组织学改变的相关性研究

^13C -Urea breath test and Helicobacter pylori infection and gastric inflammation in histological change

目的探讨^13C-尿素呼气试验（^13C-UBT）定量检测结果与幽门螺杆菌定植数量及胃黏膜炎症程度的关系。方法选择具有上消化道症状的患儿进行^13C-UBT检测，将检测结果阳性（DOB值δ‰≥4．0）的95例患儿作为研究对象，对其进行胃镜检查，同时取胃黏膜做组织病理学检查，对^13C-UBT定量结果与胃内幽门螺杆菌感染的严重程度及胃黏膜炎症之间的差异进行相关性分析。结果胃黏膜幽门螺杆菌重度感染组与轻、中度感染组之间，DOB值差异具有统计学意义（P〈0．05）。胃黏膜炎症重度与轻、中度之间的DOB值差异具有统计学意义（P〈0．05）。DOB值与胃黏膜幽门螺杆菌的定植量及胃黏膜炎症程度之间有一定的相关性。结论^13C-UBT定量检测结果能提示胃内幽门螺杆菌定植数量，但两者之间缺乏精确的定量关系。DOB值与胃黏膜炎症程度之间呈正相关。

Objective To investigate the correlation about the quantitative test result of ^13 C-urea breath test（^13C-UBT） with the quantity of Helicobacter pylori（ H. pylori） and the degree of gastric mucosal inflammation. Methods ^13C-UBT was tested in the children with upper gastrointestinal symptoms. Ninety-five cases of the children with positive result（ DOBδ‰≥4. 0） underwent endoscopy and gastroscopic biopsy. The correlation was analyzed between the result of the ^13C-UBT and the severity of gastric H. pylori infection and gastric muco- sal inflammation. Results There were significant differences about DOB values between the group with severe gastric H. pylori infection and the group with mild to moderate infection （ P 〈 0. 05 ）, the same result was ob- served between the group with severe gastric mucosal inflammation and the group with mild to moderate inflammarion（ P 〈0. 05 ）. There was certain correlation between DOB value and the amount of gastric H. pylori colonization and mucosal inflammation. Conclusion The quantitative test result of ^13C-UBT could indicate the number of gastric H. pylori colonization,but lack a precise quantitative relationship between them; There was positive correlation between the DOB values and the degree of gastric inflammation.