纤维蛋白原在消化系统肿瘤中的水平

Expression of Fibrinogen in Digestive System Neoplasms

目的探讨消化系统肿瘤中纤维蛋白原(FIB)的水平及临床意义。方法使用全自动血凝分析仪检测126例食管癌、92例胰腺癌、138例胃癌、157例大肠癌、135例肝癌、50例体检正常人血浆中的FIB,用全自动电化学发光分析仪检测相应的癌胚抗原(CEA)。结果在食管癌、胰腺癌、胃癌、大肠癌、肝癌及正常人血浆中FIB的阳性率分别为14.3%、42.4%、60.1%、62.4%、45.9%、10.0%,CEA在相应肿瘤人群中阳性率分别为12.7%、25.0%、42.8%、38.9%、33.3%。在胰腺癌、胃癌、大肠癌、肝癌患者中FIB阳性率明显高于正常人,差异有统计学意义(P<0.05);而在食管癌患者与正常人间FIB阳性率差异无统计学意义(P>0.05)。在胰腺癌、胃癌、大肠癌、肝癌患者中FIB阳性率明显高于CEA阳性率,差异有统计学意义(P<0.05);而在食管癌患者中FIB与CEA阳性率差异无统计学意义(P>0.05)。结论在胰腺癌、胃癌、大肠癌、肝癌患者血浆中FIB阳性率明显增高,有望成为肿瘤早期诊断的指标;而在食管癌患者血浆中FIB阳性率与CEA阳性率相近,提示FIB增高有器官特异性。

Objective To investigate the expression and clinical significance of fibrinogen （FIB） in digestive system neoplasms. Methods The expression of FIB was detected by auto coagulation analyzer in the plasma of 126 cases of esophagus cancer, 92 cases of pancreatic cancer, 138 cases of gastric cancer, 157 cases of large intestine cancer, 135 cases of hepatocellular cancer and 50 normal health people. The expression of carcinoembryonic antigen （CEA） was detected by automatic electrochemical luminescence analyzer. Results The positive rates of FIB in esophagus cancer, pancreatic cancer, gastric cancer, large intestine cancer, hepatocellular cancer and normal healthpeople were 14.3%, 42.4%, 60.1%, 62.4%, 45.9%, 10.0%, respectively. The positive rates of CEA in the digestive system neoplasms were 25.0%, 42.8%, 38.9%, 33.3%, respectively. The expression rates of FIB in pancreatic cancer, gastric cancer, large intestine cancer, hepatocellular cancer were obviously higher than those in normal health people （P 〈 0. 05） ; but there was no difference between esophagus cancer and normal health peop}e （P 〉 0.05 ）. The expression of FIB in pancreatic cancer, gastric cancer, large intestine cancer, hepatocellular cancer was obviously higher than CEA （P 〈 0.05） ; but there was no difference between esophagus cancer and normal health people （P 〉 0.05）. Conclusion The positive rates of FIB in pancreatic cancer, gastric cancer, large intestine cancer, hepatocellular cancer were increased obviously, FIB is a reliable index in early diagnosis of various cancers. There is no significantly difference in the expression of FIB between esophagus cancer and normal health people. It suggests FIB has tissue-specific character.