消癌平注射液联合FOLFOX6方案化疗治疗晚期胃癌的疗效观察

Clinical Observation of Xiaoaiping Injection Combined with Chemotherapy on the Treatment of Advanced Gastric Cancer

目的观察消癌平注射液联合化疗治疗晚期胃癌临床疗效及安全性。方法将68例晚期胃癌患者按随机数字表法分为治疗组33例、对照组35例,对照组仅给予FOLFOX6方案化疗(奥沙利铂85 mg.m2,静滴2h,第1天;亚叶酸钙400 mg.m2,静滴,第1天;5-氟尿嘧啶400 mg.m2,静滴2 h,第1天;5-氟尿嘧啶2 400～3 000 mg.m2,持续静脉泵入46 h,14 d为1疗程),而治疗组在FOLFOX6方案化疗的同时,给予消癌平注射液60 mg.d+质量分数5%葡萄糖250 mL,静滴,共7 d,14 d为1周期,4周期为1疗程,治疗至少2疗程评价疗效。结果治疗组有效率54.54%(18/33),对照组48.57%(17/35);治疗后KPS评分治疗组为(80.6±9.12)分,对照组为(80.28±5.91)分。2组均未发生严重毒副反应。结论消癌平注射液联合FOLFOX6方案治疗晚期胃癌疗效优于单纯化疗,能明显改善晚期胃癌患者的生活质量,且安全性好。

Objective To observe the efficacy and safety of xiaoaiping injection combined with chemotherapy in the treatment of patients with advanced gastric cancer. Methods Sixty-eight patients with advanced gastric cancer were randomly divided into the trial group （33 patients） and the control group （35 patients）. The 35 patients of the control group were treated by FOLFOX6 regimen, meanwhile, 33 patients of the trial group received a regimen of 60 mg · d xiaoaiping injection for 7 days on the chemotherapy cycle. Fourteen days were one cycle, and 4 cycles were one course of treatment. The efficacy was evaluated after 2 courses of treatment. Results The response rate was 54.54% （18/33） in the trial group, and was 48.57% （17/35） in the control group （P 〈0.05）. The KPS score after treatment was （80.6 ±9.12） in the trial group, and was （80.28±.91 ） in the control group. The toxicities of the two groups were mild. Conclusion Xiaoaiping injection combined with chemotherapy are better than chemotherapy alone in the treatment of advanced gastric cancer. It can improve the quality of life of the patients with ad- vanced gastric cancer, and the toxicities are mild.