摘要
目的比较3种5-羟色胺3受体拮抗剂治疗顺铂所致呕吐的经济学效果。方法 3组患者顺铂化疗期间分别予以帕洛诺司琼(A组)、阿扎司琼(B组)及格拉司琼(C组),观察对于呕吐反应防治的有效率,并采用药物经济学方法进行成本-效果分析。结果 A、B、C组对于急性呕吐的有效率分别为85.0%、80.4%、78.6%,比较差异无统计学意义(P>0.05);成本分别为925.2元、349.5元及276.7元,其中C组所需成本最低(P均<0.05)。但对于延迟性呕吐的有效率,A组明显高于其他2组(P均<0.05),成本-效果分析也以A组最佳。结论对于顺铂所致急性呕吐,格拉司琼是较为合理方案;而对于延迟性呕吐,帕洛诺司琼更优。
Objective To evaluate the cost-effectiveness of three 5-hydroxy tryptamine 3 (5-HT3 ) receptors suppressant for cisplatin-induced vomiting. Methods All the patients received cisplatin chemotherapy were randomly divided into three groups according to the preventing schemes: group A (treated with palonosetron) ,group B (treated with azasetron) and group C (treated with granisetron). The data were analyzed by using pharmacoeconomic cost-effectiveness analysis. Results The response rate of prevention of acute vomit were 85.0% ,80.4% ,78.6% in group A, B, C ( P 〉 0.05 ) ; the costs in group A, B, C were 925.2,349.5 and 276.7 yuan ( P 〈 0.05 ) ,the costs in group C was the lowest. While palonosetron ( group A) was superior to azasetron ( group B ) and granisetron ( group C) in the prevention of chronic vomit ( P 〈 0.05 ), the result of cost-effectiveness analysis showed that group A was the best. Conclusion For the prevention of acute vomit induced by cisplatin, granisetron is the most economical one; while for the chronic vomit,palonosetron is the most.
出处
《肿瘤基础与临床》
2012年第5期414-417,共4页
journal of basic and clinical oncology
关键词
成本-效果分析
顺铂
呕吐
5-羟色胺
cost-effectiveness analysis
cisplatin
vomiting
5-hydroxy tryptamine