岗梅不同药用部位抗炎、止咳药效比较研究

Pharmacodynamics comparative study on anti-inflammatory,relieving cough effects of the different parts of herba Ilex asprella

目的研究岗梅不同药用部位抗炎、止咳药效的差异。方法采用二甲苯致小鼠耳廓肿胀法、氨水引咳法观察岗梅根、茎、叶、根茎混合物抗炎、止咳作用,比较不同部位药效差异。结果与空白对照组比较,岗梅根、茎、叶、根茎混合物均可显著抑制致炎小鼠耳廓肿胀(P<0.01),耳肿胀抑制率分别达62.11%、43.95%、53.90%、57.38%;岗梅根、茎、叶、根茎混合物对致咳小鼠咳嗽潜伏期无显著性差异(P>0.05),但根、茎、根茎混合物可显著减少致咳小鼠5min内咳嗽次数(P<0.05)。结论岗梅根、茎、根茎混合物均具有显著的抗炎和止咳药效,但岗梅叶仅有抗炎作用。

Objective To compare the difference of effects on anti-inflammatory , relieving cough in different parts of herba llex asprella. Method Daubing xylene on ears of mice and mmonia water induced cough model were applied to evaluate and compare the anti-inflammatory and relieving cough effects in different parts of herba llex asprella. Results Compared with control group, the root, stem, leaf, and roots mixture of llex asprella groups all can inhibit the swelling of mice ears（P〈0.01 ） ,auricular swelling inhibition rate were respectively 62.11% ,43.95 % ,53.90% ,57.38% ; There was no significant difference in the frequency of mice cough（ P〉0.05 ）, but the root, stem, land roots mixture of llex asprella could remarkably reduce cough times of mice within 5 minutes（P〈0.05 ）. Conclusion The study showed that the root, stem, and roots mixture of llex asprella have obvious anti-inflammatory and relieving cough effects except the leaf only anti-inflammatory.