六味五灵片治疗抗结核药物所致肝损伤疗效观察

Therapeutic effect of Liuweiwuling tablets on liver injury induced by antitubercular agents

目的探讨六味五灵片治疗抗结核药物所致肝损伤的临床疗效。方法将72例抗结核药物所致肝损伤患者随机分为治疗组(38例)和对照组(34例),两组患者应用抗结核药物的同时,治疗组加用六味五灵片,对照组加用护肝片。两组患者疗程均为4周,且治疗结束后随访2周。比较两组患者肝功能改变。结果治疗组在治疗及随访结束后ALT、AST、TBil复常率与对照组比较,差异有显著统计学意义(P<0.01)。结论六味五灵片可以改善受损肝脏功能,减轻肝内炎性反应,治疗抗结核药物所致肝损伤效果显著。

Objective To evaluate the clinical curative effect of Liuweiwuling tablets in the treatment of hepatic lesion caused by antituberculotic agents. Methods Total of 72 cases with hepatic lesion caused by antituberculotic agents were randomly divided into the treatment group （n = 38） and control group （n = 34）. The treatment group was given antituberculotic agents combined with Liuweiwuling tablets. The control group was given antituberculotic agents combined with Hugan tablets. The course of treatment was 4 weeks. All patients were followed-up for 2 weeks after the treatment. And liver function were observed after therapy. Results After the treatment, ALT, AST, TBil levels of the treatment group were better than that of the control group. Conclusions Liuweiwuling tablets can recover liver function and relieve the liver inflammation. It is effective on the treatment of hepatic lesion caused by antituberculotic agents.