临界视觉闪烁频率在肝硬化失代偿期患者轻型肝性脑病诊断中的价值

Diagnosis of minimal hepatic encephalopathy with critical flicker-fusion frequency in patients with decompensated liver cirrhosis

目的探讨临界视觉闪烁频率(CFF)对肝硬化失代偿期患者轻型肝性脑病诊断上的应用价值。方法对160例肝硬化失代偿期患者进行CFF检测,并与对照组进行比较。结果肝硬化失代偿期患者CFF值<39.0Hz以下者占多数(76.25%),而对照组CFF值均>40.0Hz,两组间比较差异有统计学意义(t=7.35,P<0.01)。CFF值<39.0Hz以下的患者平均血氨异常率为78.96%,分别与CFF值>39.0Hz各组比较,差异有统计学意义(t=5.65,P<0.01)。结论检测CFF值是肝硬化失代偿期患者及早发现轻型肝性脑病的一项客观而敏感的诊断方法 。

Objective To evaluate the diagnostic value of critical fricker frequency （CFF） in minimal hepatic encephalopathy （MHE） induced by liver cirrhosis. Methods Total of 160 patients with decompensated liver cirrhosis were recruited in the study, and normal subjects were served as controls. Results The abnormal rates of CFF 〈 39.0 Hz in patients with decompensated hepatic cirrhosis was 76.25%, while CFF in the control group all 〈 40.0 Hz. The difference between the two groups was statistically significant （t = 7.35, P 〈 0.01）. The rate of average abnormal blood ammnoia in patients with CFF 〈 39.0 Hz was 78.96%, with statistical significance compared with patients with CFF 〉 39.0 Hz （t = 5.65, P 〈 0.01）. Conclusions The detection of CFF is impersonal and sensitive for early detection of MHE in patients with decompensated cirrhosis.