紫杉醇、卡铂和顺铂对裸鼠荷人卵巢癌移植瘤抑瘤效果的实验研究

Etudy of the efficacy of taxol,carboplatin and cisplatin on the human ovarian carcinoma xenografts in BALB/c-nu mice

目的:观察紫杉醇、卡铂和顺铂对裸鼠荷人卵巢癌移植瘤的抑瘤效果。方法:选取2例本实验室已建立的裸鼠荷人卵巢癌移植瘤模型(模型1和模型2)分别给予生理盐水、紫杉醇、卡铂和顺铂,动态测量各组移植瘤体积,药物的抑瘤效果以肿瘤的相对增殖率表示。结果:模型1和模型2的移植瘤生长速度不同,二者分别于接种后第7天和第3周移植瘤体积均值超过100 mm3。紫杉醇、卡铂和顺铂均可显著抑制模型1和模型2移植瘤的生长(P均<0.001)。处死裸鼠时,3种药物对模型1和模型2的肿瘤相对增殖率分别为44.93%、27.1%、11.77%和49.50%、28.97%、6.79%。结论:紫杉醇、卡铂和顺铂单一使用时在实验周期内对人卵巢癌裸鼠移植瘤均有很好的抑瘤效果,可以应用裸鼠荷人卵巢癌移植瘤模型研发新药。

Objective： To test the efficacy of taxol,carboplatin and cisplatin on the human ovarian carcinoma xenografts.Methods： The P5 xenografts of model 1 and model 2 were randomly devided into 4 groups（blank controller,taxol,carboplatin,and cisplatin）,respectively.The efficacies of the above drugs were evaluated by relative proliferation rate.Results： The growth speed of model 1 and model 2 was different.The average volume of the xenografts reached 100 mm3 at 7 days and 3 weeks after inoculation,respectively.Taxol,carboplatin and cisplatin could slow down the growth rate of the xenografts originated from model 1and model 2 significantly.The relative growth rate of model 1 were 44.93%,27.1% and 11.77% in taxol,carboplatin,and cisplatin group,respectively.Correspondingly,those of model 2 were 49.50%,28.97%,6.79%,respectively.Conclusion： All the three drugs have anticancer activity to the human ovarian carcinoma xenografts in BALB/c-nu mice in the experiment period.It＇s helpful to develop new anticancer drugs.