摘要
高血压、心房颤动均为最常见的心血管疾病,二者通常并存,其发病率随年龄增长而增加。心房颤动的危险因素很多,高血压是主要危险因素。心房重构、神经内分泌激素异常、心肌组织纤维化、动脉粥样硬化等均与心房颤动密切相关。降压治疗可减少心房颤动风险,心房颤动增加脑卒中风险,对心房颤动的风险分层、应用华法林有效预防脑卒中形成。一些新的抗凝剂无需检测凝血酶原时间的国际化标准比,应用更方便,有良好的应用前景。
Hypertension and atrial fibrillation are the most common cardiovascular disorders. Both conditions frequently coexist and their prevalence increases rapidly with aging. Among many risk factors predisposing to the development of atrial fibrillation, hypertension is the main risk factor. Several pathophysiologic mechanisms （such as structural changes, neurohormonal activation, fibrosis, atherosclerosis, etc. } have been advocated to explain the onset of atrial fibrillation. Antihypertensive treatment decreases the risk of atrial fibrillation which leads to stroke. The risk stratification for atrial fibrillation and the prevention of thromboembolism with warfarin are effective in the prevention of stroke. Quite recently, new classes of anticoagulants that do not require international normalized ratio monitoring have been introduced with promising results.
出处
《心血管病学进展》
CAS
2012年第5期596-600,共5页
Advances in Cardiovascular Diseases
关键词
高血压
心房颤动
降压治疗
抗凝治疗
hypertension
atrial fibrillation
antihypertensive treatment
anticoagulants
