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核磁共振技术在药物分析鉴定中的应用 被引量:31

Application of NMR Techniques in Pharmaceutical Assay
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摘要 对核磁共振的特点及其在药物分析鉴定中应用的技术优势进行了分析。并通过实例展示了核磁共振检测试验方法多、信息丰富和定量分析方法灵活等技术特点。在3个具体实例中,利用核磁共振技术同步实现了混合物样品中主要成分或异构体的认定和含量(或相对含量)测量,达到了"快速"检测的效果。 The advantages and applications of NMR in the analysis and identification of pharmaceutical materials were discussed,based on paper investigation and our own experience.The real cases showed that NMR could play an unique role in the pharmaceutical assay due to its distinctive technical characteristics,such as multi-methods available,plenty of information provided and flexibility of qNMR.In these cases,the main components in each of mixtures were identified and their contents(or relative cintens) were determined simultaneously by NMR techniques within a relatively short time.
出处 《分析测试学报》 CAS CSCD 北大核心 2012年第9期1081-1088,共8页 Journal of Instrumental Analysis
关键词 定量核磁共振 选择性实验 扩散实验 药物分析 qNMR selective NMR experiments dosy pharmaceutical assay
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