分子印迹微米微球的合成方法及在固相萃取中的应用研究进展

Progresses on Synthesis Methods of Molecularly Imprinted Microspheres and Their Applications in Solid-phase Extraction

与分子印迹本体聚合物相比,分子印迹微米微球(MIMs)具有均匀规整的形状和良好的动力学特征,因而被广泛用于固相萃取(SPE)、色谱分离、化学传感器以及药物投递等研究领域。MIMs的合成方法主要有悬浮聚合法、多步溶胀聚合法和沉淀聚合法。该文追踪了近10年有关MIMs的文献,对其上述3种合成方法进行了总结,并比较了其优缺点;同时对MIMs在固相萃取中的应用进展进行了总结和评述,对其未来发展方向进行了展望。

Compared with bulk molecularly imprinted polymer,molecularly imprinted microspheres（MIMs） exhibit more uniform size and much better dynamic characteristics.Thus,MIMs are widely used in the applications of solid-phase extraction（SPE）,chromatographic separation,biosensor and drug delivery system.The main synthesis methods of MIMs are suspension polymerization,multi-swelling polymerization（MSP） and precipitation polymerization（PP）.In this review,the research literatures on MIMs published in recent 10 years were tracked.The three synthesis methods of MIMs were summarized and commented.The advantages and disadvantages of those synthesis methods were compared.Meanwhile,the applications of MIMs in SPE were reviewed,and the prospect of synthesis and applications of MIMs was also put forward.