325例辅助受孕儿24月龄时精神运动发育水平研究

Psychomotor development at 24 months old in 325 children conceived with use of assisted reproductive technology

【目的】通过研究辅助受孕儿24月龄时的精神运动发育水平,以评价辅助生殖技术的安全性。【方法】采用前瞻性对照研究方法,实验组为人工辅助受孕妊娠儿,对照组为自然受孕妊娠儿,将两组人群在母亲年龄、产次、家庭社会阶层、双亲受教育程度等几个方面进行配对,均自母亲孕28周起入组登记定期随访收集相关资料并由经过培训的指定专业人员采用CDCC婴幼儿发育量表定期对其行精神运动发育评估至24月龄,获得智力发育指数及运动发育指数。【结果】辅助受孕儿童至24月龄时其精神运动发育水平与自然受孕儿童相比差异无统计学意义(P>0.05)。【结论】辅助受孕儿童24月龄时的精神运动发育水平正常,初步证明我国目前的辅助生殖技术是安全的。

[Objective] To compare the psychomotor development at 24 months old in children born after assisted conception with a control group of children conceived naturally. [Methods] A mached control study was performed on the psychomotor development of 24 months old in children conceived with use of assisted reproductive technology. The control group was matched according to maternal age,parity, social class and level of maternal education. The suitable mothers were invited to participate at 28 weeks of gestation and were followed up to delivery. The children of two groups were followed up to 24 months old and a formal developmental assessment was done with the CDCC Scales of Children Development. [Result] No statistically significant differences were found in the mental development index （MDI） and psychomotor development index （PDI） between study and control groups,as asssessed by the CDCC Scales. [Conclusion] The level of psychomotor development at 24 months old in children born after assisted conception was normal. So the assisted reproductive technology is safety in china.