Survivin在子宫腺肌病中的表达及与VEGF相关性研究

Expression of Survivin in Adenomyosis and its Relationship with VEGF Prote in adenomyosis

目的探讨凋亡抑制基因Survivin在子宫腺肌病的表达及其与VEGF的相关性。方法应用免疫组织化学S-P法,检测50例子宫腺肌病异位及在位内膜组织中Survivin、VEGF蛋白的表达,并与正常在位子宫内膜组织30例进行对照。结果子宫腺肌病异位内膜组织中Survivin蛋白阳性表达率为80%,明显高于正常内膜及在位内膜组织的表达率16.67%、16%(P<0.05);子宫腺肌病异位内膜组织中VEGF蛋白阳性表达率为56%,明显高于正常内膜及在位内膜组织的表达率38%、20%(P<0.05);Survivin蛋白表达与VEGF蛋白呈正相关(P<0.01)。结论 Survivin可通过抑制异位内膜细胞凋亡,参与血管形成对子宫腺肌病的发生、发展起作用;Survivin与VEGF在子宫腺肌病的发生、发展中起协同作用。

Objective To study the relationship of apoptosis - related gene Survivin with VEGF protein in adenomyosis. Methods The expressions of Survivin, VEGF protein were deteeted by immunohistochemicalmethod （SP） in ectopic and eutopic endometrium of adenomyosis from 50 cases, and compared with that in eutopic endometrium from endometrium 30 caseswithout adenomyosis. Results The expression rate of Survivin protein in ectopic endometrium of adenomyosiswasmuch higher than that in normal endometrial cells. The expression rate of VEGF protein in ectopic endometrium of adenomyosiswasmuch higher than that in normal endometrial cells. The Survivin was positively corelated to VEGF. Conclusion Survivin may play an important role in pathogenesis of adenomyosis. With Survivin gene, apop tosis - related gene VEGF may have a synergic role in the formation and progression of adenomyosis