摘要
目的观察异甘草酸镁治疗中毒性肝炎的疗效。方法160例临床确诊为中毒性肝炎住院患者完全随机分为观察组和对照组,各80例。2组均常规给予维生素及氨基酸类等药物治疗,观察组在此基础上给予异甘草酸镁注射液150mg静脉滴注,对照组在此基础上给予还原型谷胱甘肽注射液1.8g静脉滴注,1次/d,疗程均为4周。观察2组患者的症状改善情况、肝功能及不良反应。1个月后治疗无效者换用其他治疗。结果观察组乏力好转率95.0%(76例),好转时间10(5-15)d;对照组分别为86.2%(69例)、18(14-22)d。观察组消化道症状好转率93.8%(75例),好转时间12(8-16)d;对照组分别为83.8%(67例)、21(16-26)d。观察组ALT好转率97.5%(78例),好转时间15(10-20)d;对照组分别为88.8%(71例)、25(20-30)d。观察组血清总胆红素好转率96.2%(77例),好转时间14(9-19)d;对照组分别为87.5%(70例)、23(18-28)d。观察组乏力、消化道症状、ALT、总胆红素好转率和好转时间均明显优于对照组,差异均有统计学意义(均P〈0.05)。观察组显效58例(72.5%),有效18例(22.5%),总有效率95.0%(76例),对照组显效50例(62.5%),有效19例(23.8%),总有效率86.3%(69例)。观察组总有效率明显高于对照组,差异有统计学意义(P〈0.05)。2组均无明显不良反应。结论异甘草酸镁治疗中毒性肝炎的疗效优于还原型谷胱甘肽。
Objective To observe magnesium isoglycyrrhizinate (MgIG) in the treatment of toxic hepatitis. Methods One hundred and sixty toxic hepatitis patients were randomly divided into treatment group (80 cases ) and control group (80 cases). Both groups had a vitamin, amino acids and other drugs. The observation group was given MgIG injection of 150 mg intravenous infusion on the basis of routine treatment; the control group was given 1.8 g intravenous infusion of glutathione injection. Both groups were treated for 4 weeks. Results The improvement rate of fatigue, gastrointestinal symptoms, alanine transarninase, total bilirubin in observation group were significantly better than those in the control group ( P 〈 0.05 ). The total effective rate of observation group was higher than that in control group[ 95.0% (76/80) vs 86.3% (69/80), P 〈 0.05 ]. Conclusion MgIG may be more effective than glutathione for toxic hepatitis.
出处
《中国医药》
2012年第10期1261-1262,共2页
China Medicine