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围妊娠期胰岛β细胞量动态调控机制的研究进展 被引量：4

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摘要 妊娠是一种特殊而复杂的生理过程。随着孕周的延长、体重的增加，胎盘产生的胰岛素拮抗激素如催乳素、雌激素、孕激素及皮质激素等逐渐增多，母体会出现对胰岛素的敏感性降低，从而表现出“生理性胰岛素抵抗”。此时，母体胰岛β细胞量通过代偿性扩增，分泌更多的胰岛素来满足机体的需求。
作者 王晓兢 武晓泓
机构地区 南京医科大学第一附属医院内分泌科
出处 《中华糖尿病杂志》 CAS 2012年第9期519-522,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 国家自然科学基金（81070621/H0704） 教育部留学回国人员科研启动基金（教外司留[2011]1568号） 人事部留学人员科技活动项目择优资助经费（人社厅函[2010]412号） 江苏省国际科技合作计划一重点国别和地区研发合作项目（BZ2011042） 江苏省医学重点人才项目（RC2011068）
关键词 胰岛素拮抗激素 细胞量 妊娠期 调控 敏感性降低 胰岛素抵抗 生理过程 皮质激素
分类号 R714.147 [医药卫生—妇产科学]
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参考文献24

  • 1Rieck S,White P,Schug J. The transcriptional response of the islet to pregnancy in mice[J].Molecular Endocrinology,2009.1702-1712.
  • 2Xue Y,Liu C,Xu Y. Study on pancreatic islet adaptation and gene expression during pregnancy in rats[J].Endocrinology,2010.83-97.
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同被引文献42

  • 1马润玫,杜明钰,王丹丹,张燕.妊娠合并糖尿病的流行病学现状[J].中国实用妇科与产科杂志,2007,23(6):455-458. 被引量：47
  • 2杨会平,李玉虹,郭银过,朱秀丽.妊娠期糖尿病治疗对妊娠结局影响的研究[J].实用医技杂志,2007,14(20):2723-2724. 被引量：9
  • 3International Association of Diabetes Pregnancy Study Groups Con-sensus Panel,Metzger BE,Gabbe SC,et al. International associa-tion of diabetes and pregnancy study groups recommendations onthe diagnosis and classification of hyperglycemia in pregnancy. Dia-betes Care,2010,33(3) :676-682.
  • 4Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simplemathematical model[ J：. Diabetes, 1995,44:249-256.
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  • 8Wu X, Wang L, Schroer S, et al. Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice [ J ]. Diabetologia, 2009,52:2130-2141.
  • 9Rieck S, White P, Schug J, et al. the islet to pregnancy in mice [ J ] 1702-1712. The transcriptional response of . Mol Endocrinol, 2009,23.
  • 10Xue Y, Liu C, Xu ：, et al. Study on pancreatic islet adaptation and gene expression during pregnancy in rats [ J ]. Endocrine, 2010,37 : 83 -97.

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中华糖尿病杂志
2012年 第9期

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