不同金属烤瓷冠对牙龈组织血管内皮生长因子水平的影响

The effect of different porcelain fused to metal crowns on VEGF level of the gingival tissue

目的观察不同金属烤瓷内冠修复体对牙龈组织血管内皮生长因子(VEGF)水平的远期影响。方法选择行钴铬合金及钛合金烤瓷全冠修复3年后162颗牙,分为T1组82颗(钴铬合金),T2组80颗(钛合金),以T1组和T2组的对侧或对颌健康同名牙作对照组,记录实验组和对照组牙龈指数(GI)、探诊深度(PD)、并用滤纸条法收集牙龈沟液(GCF),测定龈沟液的量,用酶联免疫吸附法测定龈沟液中血管内皮生长因子(VEGF)的水平。结果 T1组在临床牙周指标(GI,PD)与其对照组比较无统计学差异(P>0.05),龈沟液的量(GCF)及血管内皮生长因子(VEGF)的水平有统计学差异(P<0.05)。而T2组的各项指标与其对照组比较,均有统计学差异(P<0.01)。T1与T2组之间比较各项指标有统计学差异(P<0.05)。结论不同金属烤瓷冠对牙周组织的远期影响不同,钴铬合金烤瓷冠修复比钛合金烤瓷冠有更好的临床效果,远期影响较小。

Objective To observe the long-term effect of different porcelain fused to metal（PFM）internal crowns restoration on the VEGF（vascular endothelial growth factor）level of gingival tissues.Methods To choose 162 teeth repaired after 3 years by Cobalt-Chromium alloy PFM（Co-Cr-PFM）and Titanium alloy PFM（Ti-alloy-PFM） crowns,and dividing them two groups,Group T1 consists of 82 teeth（Co-Cr alloy）,and group T2 includes 80 teeth（Titanium alloy）.With the contralateral or jaw same-name health teeth of group T1 and T2 as the control group,to keep a record of the gingival index（GI） and probing depth（PD） of the experimental group and control group.To collect the gingival crevicular fluid（GCF）with the filter strip method and measure GCF amount,and determine the level of VEGF in the gingival crevicular fluid by ELISA（enzyme-linked immuno sorbent assay）.Results There are no statistical differences（P0.05） in Clinical periodontal index（G1,PD） between the group T1 and control group,and there are statistical differences between the amount of gingival crevicular fluid（GCF） and VEGF（P0.05）.The above indexes between group T2 and control group have the statistical differences（P0.01）.There is statistical differences（P0.05） between group T1 and group T2.Conclusion The different PFM crowns have different long-term impacts on periodontal tissues.The repair by Co-Cr-PFM crowns has better clinical effect and less long-term influence than that by Ti-alloyPFM crowns.