慢性阻塞性肺病急性加重期CRP、CK-MB、LDH水平变化的临床意义

Changes of serum CRP, CK-MB and LDH levels in patients with chronic obstructive pulmonary disease at acute exacerbation and their clinical significance

目的探讨血清C-反应蛋白(CRP)、磷酸肌酸激酶同工酶(CK-MB)和乳酸脱氢酶(LDH)在慢性阻塞性肺病(COPD)急性加重期浓度变化及相关临床意义。方法测定60例COPD患者急性加重期血清CRP、CK-MB和LDH水平和动脉血氧分压(PaO2),45例健康体检者血清CRP、CK-MB和LDH水平。结果急性期COPD患者血清CRP、CK-MB和LDH水平与健康体检者比较差异均有统计学意义(P<0.05)。相关性分析结果显示,COPD急性期患者CRP与CK-MB、LDH之间及CK-MB与LDH之间呈正相关(P<0.05),COPD急性期患者PaO2与CRP、CK-MB、LDH之间呈负相关(P<0.01)。结论 COPD急性加重期血清CRP浓度高,机体存在血氧饱和度低、心肌功能异常及严重感染;联合检测CRP、CK-MB和LDH浓度可以为COPD的病情评估、治疗及预后提供相关的评价指标。

Objective To investigate the changes in the serum levels of C-reactive protein （CRP）, creatine ki- nase MB isoenzyme （CK-MB） and lactate dehydrogenase （LDH） in patients with chronic obstructive pulmonary dis- ease （COPD） at acute exacerbation, and to analyze their clinical significance. Methods The serum levels of CRP, CK-MB, LDH and PaO2 were measured in 60 patients with COPD at acute exacerbation （the study group） and 45 healthy subjects （the control group）. Results The serum levels of CRP, CK-MB, and LDH in the study group were significantly higher than those in the control group （P〈0.05）. In the study group, positive correlation was found be- tween CRP and CK-MB, LDH, as well as between CK-MB and LDH （P〈0.01）, while negative correlation was found between PaO2 and CRP, CK-MB, LDH （P〈0.01）. Conclusion Combined detection of serum CRP, CK-MB and LDH can provide reliable indicators for the diagnosis, prevention and treatment of COPD.