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清开灵注射液可缩小大鼠缺血-再灌注心肌损伤范围 被引量:1

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摘要 心肌缺血再灌注损伤能够引起心肌细胞大量凋亡,可导致心脏结构的重构和心律失常Ⅲ。临床表现为ST段抬高,心肌损伤范围增大,心肌形态学改变等。本实验在成功建立急性心肌缺血模型后,应用清开灵注射液,在心电图、心肌损伤范围,心肌形态学方面观察,初步探讨清开灵注射液(QKL)的作用机制。
出处 《中国冶金工业医学杂志》 2012年第5期580-581,共2页 Chinese Medical Journal of Metallurgical industry
基金 吉林省教育厅:"十一五"科学技术研究项目(吉教科合字[2008]第439号)
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  • 1陈宝平,毛红娇,范芳燕,李江,夏强.缝隙连接脱耦联剂庚醇对大鼠缺血-再灌注损伤心肌的保护作用[J].中国病理生理杂志,2005,21(6):1071-1075. 被引量:8
  • 2Schulz R, Boengler K, Dodoni G, et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning[ J]. Cardiovasc Res, 2005, 67 (2) : 234 - 244.
  • 3Paradies G, Petrosilto G, Pistolese M, et al. Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin[J]. Circ Res, 2004, 94(1): 53-59.
  • 4Flameng W, Borgers M, Daenen W, et al. Uhrastructural and cytochemical correlates of myocardial protection by cardiac hypothermia in man [ J ]. J Thorac Cardiovasc Surg, 1980, 79(3): 413-424.
  • 5Emaus RK, Grunwald R, Lemaslers JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat liver mitochondria: spectral and metabolic properties [ J ]. Biochim Biophys Acta, 1986, 850(3) : 436 -448.
  • 6Elizabeth AF, James DM, Takttro T, et al. Myocardial mitochondrial calcium accumulation modulates nuclear cal- cium accumulation and DNA. fragmentation [ J ]. Amm Thorac Surg, 1995, 60(2) : 338 -344.
  • 7Baumgartner HK, Gerasimenko JV, Thorne C, et al. Calcium elevat ion in mitochondria is the main Ca^2+ requirement for mPTP opening [ J ]. J Biol Chem, 2009, 284 ( 31 ) : 20796 - 20803.
  • 8Penna C, Perrelli MG, Raimondo S, et al. Postconditioning induces an anti - apoptotic effect and preserves mitochondrial integrity in isolated rat hearts[ J]. Biochim Biophys Acta, 2009, 1787 (7) : 794 - 801.
  • 9Cruciani V, Mikalsen SO. Connexins, gap junctional intercellular communication and kinases [ J ]. Biol Cell, 2002, 94(7 -8) : 433 -443.
  • 10Goubaeva F, Mikami M, Giardina S, et al. Cardiac mitochondrial connexin 43 regulates apoptosis [ J ]. Biochem Biophys Res Commun, 2007, 352( 1): 97- 103.

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