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自噬与肾脏固有细胞损伤 被引量：3

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摘要 近年来,自噬（autophagy）已成为生物学领域一个新的研究热点,它在人类疾病发生发展中的作用也逐渐受到重视.肾脏固有细胞如足细胞、系膜细胞、内皮细胞以及肾小管上皮细胞等经常会受到免疫因子、肾毒物、缺血缺氧等各种理化因素的刺激,这些刺激往往会诱导细胞损伤,导致肾脏疾病的发生.自噬作为维持细胞内环境稳定的一个重要机制,研究发现它与肾脏固有细胞处理各种应急的病理生理过程也存在着密切关系.本文主要对自噬与各种原因所致肾脏固有细胞损伤的研究进展进行概述,以期较为全面地了解这方面的研究动态,为自噬在肾脏疾病领域的研究提供参考.
作者 谭进 刘华锋 陈孝文
机构地区 广东医学院附属医院肾病研究所
出处 《中国中西医结合肾病杂志》 2012年第9期836-838,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 国家自然科学基金资助项目(No.30971370/C140405)
关键词 肾脏疾病 细胞损伤 自噬 肾小管上皮细胞 病理生理过程 固有细胞 细胞内环境 人类疾病
分类号 R692 [医药卫生—泌尿科学]
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参考文献24

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二级参考文献20

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共引文献5

同被引文献47

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引证文献3

二级引证文献10

中国中西医结合肾病杂志
2012年 第9期

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