Overlapping Cardiac Programs in Heart Development and Regeneration 被引量：1

Overlapping Cardiac Programs in Heart Development and Regeneration

导出

摘要 Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine,one of the most urgent clinical needs for heart failure.Here we present a review on zebrafish heart development and regeneration,with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart,as well as cellular and molecular programs in adult zebrafish heart regeneration.We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration.A brief perspective highlights several important and promising research areas in this exciting field. Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine,one of the most urgent clinical needs for heart failure.Here we present a review on zebrafish heart development and regeneration,with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart,as well as cellular and molecular programs in adult zebrafish heart regeneration.We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration.A brief perspective highlights several important and promising research areas in this exciting field.

作者 Yi-Song Zhen Qing Wu Cheng-Lu Xiao Nan-Nan Chang Xu Wang Lei Lei Xiaojun Zhu Jing-Wei Xiong

机构地区 Institute of Molecular Medicine State Key Laboratory of Cardiovascular Disease

出处《Journal of Genetics and Genomics》 SCIE CAS CSCD 2012年第9期443-449,共7页 遗传学报（英文版）

基金 supported by the grants from the National Basic Research Program of China(Nos.2010CB529503 and 2012CB944501) the National Science Foundation of China(Nos.30971662 and 31000644)

关键词 Cardiac progenitors Heart development Heart regeneration Zebrafish Cardiac progenitors Heart development Heart regeneration Zebrafish

分类号 Q344.5 [生物学—遗传学] Q813 [生物学—生物工程]

引文网络
相关文献

参考文献57

1Cai, C.L., Martin, J.C., Sun, Y., Cui, L., Wang, L., Ouyang, K., Yang, L., Bu, L., Liang, X., Zhang, X., Stallcup, W.B., Denton, C.E, McCulloch, A., Chen, J., Evans, S.M., 2008. A myocardial lineage derives from Tbxl8 epicardial cells. Nature 454, 104--108.
2Choi, W.Y., Poss, K.D., 2012. Cardiac regeneration. Curr. Top. Dev. Biol. 100, 319--344.
3Christoffels, V.M., Grieskamp, T., Norden, J., Mommersteeg, M.T., Rudat, C., Kispert, A., 2009. Tbxl8 and the fate of epicardial progenitors. Nature 456, E8-E9.
4de Pater, E., Clijsters, L., Marques, S.R., Lin, Y.F., Garavito-Aguilar, Z.V., Yelon, D., Bakkers, 3., 2009. Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development 136, 1633--1641.
5Evans, S.M,, Yelon, D., Conlon, F.L., Kirby, M.L., 2010. Myocardial lineage development. Circ. Res. 107, 1428-1444.
6Fishman, M.C., Chien, K.R., 1997. Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099--2117.
7Fishman, M.C., Olson, E.N., 1997. Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.
8Gupta, V., Poss, I.D., 2012. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 484, 479-484.
9Hami, D., Grimes, A.C., Tsai, H.J., Kirby, M.L., 2011. Zebrafish cardiac development requires a conserved secondary heart field. Development 138, 2389--2398.
10Hsieh, RC., Segers, V.F., Davis, M.E., MacGillivray, C., Gannon, J., Molkentin, J.D., Robbins, J., Lee, R.T., 2007. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian car- diomyocytes after injury. Nat. Med. 13, 970-974.