摘要
A new and efficient synthetic route to hydroxymethylated-3,4-ethylenedioxylthiophene （EDOT-MeOH） was developed by a simple four-step sequence, and its global yield was approximately 41.06%. The poly（hydroxymethylated- 3,4-ethylenedioxylthiophene） （PEDOT-MeOIq） film was electrosynthesized in aqueous sodium dodecylsulfate micellar solutions and characterized by different methods. The EDOT-MeOH possessed better water solubility, and lower onset oxidation potential than EDOT. The as-obtained PEDOT-MeOH film displayed good reversible redox activity, stability and capacitance properties in a monomer-free electrolyte, especially the good solubility of PEDOT-MeOH film in strong polar organic solvents such as dimethyl sulfoxide and tetrahydrofuran created a potential application in many different fields. Fluorescent spectra indicated that PEDOT-MeOH was a yellow-green-light-emitter with maximum emission at 568 rim. The as-formed PEDOT-MeOH film had good biocompatibility and was used for fabricating the electrochemical vitamin C biosensor. The proposed biosensor showed a linear range of 3× 10 ^6 mol/L to 1.2 × 10^-2 mol/L with the detection limit of 1 μmol/L, a sensitivity of 95.6 μA （mmol/L） ^-1 cm 2, and a current response time less than 10 s and a fairly good stability （The relative standard deviation was 0.43% for 20 successive assays, the proposed biosensor still retained 93.5% of bioactivity after 15 days storage. This result indicated that the prepared PEDOT-MeOH film as immobilization matrix of biologically-active species could be a promising candidate for the design and application of biosensor.
A new and efficient synthetic route to hydroxymethylated-3,4-ethylenedioxylthiophene （EDOT-MeOH） was developed by a simple four-step sequence, and its global yield was approximately 41.06%. The poly（hydroxymethylated- 3,4-ethylenedioxylthiophene） （PEDOT-MeOIq） film was electrosynthesized in aqueous sodium dodecylsulfate micellar solutions and characterized by different methods. The EDOT-MeOH possessed better water solubility, and lower onset oxidation potential than EDOT. The as-obtained PEDOT-MeOH film displayed good reversible redox activity, stability and capacitance properties in a monomer-free electrolyte, especially the good solubility of PEDOT-MeOH film in strong polar organic solvents such as dimethyl sulfoxide and tetrahydrofuran created a potential application in many different fields. Fluorescent spectra indicated that PEDOT-MeOH was a yellow-green-light-emitter with maximum emission at 568 rim. The as-formed PEDOT-MeOH film had good biocompatibility and was used for fabricating the electrochemical vitamin C biosensor. The proposed biosensor showed a linear range of 3× 10 ^6 mol/L to 1.2 × 10^-2 mol/L with the detection limit of 1 μmol/L, a sensitivity of 95.6 μA （mmol/L） ^-1 cm 2, and a current response time less than 10 s and a fairly good stability （The relative standard deviation was 0.43% for 20 successive assays, the proposed biosensor still retained 93.5% of bioactivity after 15 days storage. This result indicated that the prepared PEDOT-MeOH film as immobilization matrix of biologically-active species could be a promising candidate for the design and application of biosensor.
基金
supported by the NSFC(Nos.50963002,51073074)
Jiangxi Provincial Department of Education(GJJ10678,GJJ11590)
Natural Science Foundation of Jiangxi Province(2010GZH0041,20114BAB203015)
Jiangxi Science & Technology Normal University(KY2010ZY13)
