妊娠相关血浆蛋白A和游离β-HCG在稽留流产和异位妊娠中的预测价值

Predictive value of pregnancy-associated plasma protein A and freeβ-HCG in missed abortion and ectopic pregnancy

目的:研究妊娠相关血浆蛋白A和游离β-HCG在稽留流产和异位妊娠中的预测价值。方法:回顾性分析早期妊娠孕妇128例,其中单胎正常妊娠组62例、稽留流产组37例,异位妊娠组29例,检测血清PAPP-A及游离β-HCG的浓度。结果:稽留流产组与异位妊娠组两组患者血清PAPP-A和游离β-HCG的水平明显低于正常妊娠组(P<0.01)。异位妊娠组血清PAPP-A和游离β-HCG的水平亦明显低于稽留流产组(P<0.01)。二者联合检测明显优于单项指标预测。结论:孕早期母血清联合PAPP-A和游离β-HCG水平,对早期妊娠不良结局有一定预测价值。

Objective To study the predictive value of pregnancy--associated plasma protein A and free 13--HCG in missed abortion and ectopic pregnancy. Methods A retrospective analysis of 128 cases of early pregnant women in our hospital was made, including 62 cases of normal pregnancy, 37 cases of missed abortion and 29 cases of ectopic pregnan- cy. The serum PAPP-- A and free β-- HCG concentrations were measured. Results The serum PAPP-- A and free β- HCG levels in the missed abortion and ectopic pregnancy group were significantly lower than the normal pregnancy group（P〈0.01）. The serum PAPP--A and free β-HCG levels in ectopic pregnancy group were significantly lower than those in missed abortion group（P〈0.01）. Both joint detection forecasts significantly better than the individual in- dicators. Conclusion The joint detection of PAPP-- A and free β- HCG levels in early pregnancy has some predictive values for adverse outcomes of pregnancy.