罂粟碱联合山莨菪碱在防治乳腺癌术后皮瓣坏死中的应用

目的:观察罂粟碱稀释液对术中皮瓣创面进行热湿敷及山莨菪碱静滴预防乳腺癌改良根治术术后皮瓣坏死的效果。方法:将106例乳腺癌改良根治术后患者随机分为两组,试验组使用罂粟碱稀释液对乳腺癌改良根治术术中皮瓣热湿敷及术后给予山莨菪碱针剂20mg加入0.9%氯化钠注射液100ml中静滴;对照组采用常规方式治疗进行,观察两组切口皮瓣愈合情况。结果:试验组51例中术后发生皮瓣坏死2例(3.92%),对照组48例中术后发生皮瓣坏死7例(14.58%0,差异有统计学意义(P<0.05)。结论:罂粟碱联合山莨菪碱能有效预防乳腺癌改良根治术术后皮瓣坏死。

Objective：To Observe papaverine diluent hot we/ compress and anisodamine intravenous intraoperative flap wound pre- vention of breast cancer with modified radical effect of postoperative flap necrosis. Methods ：in 106 cases of breast cancer with modified radical postoperative patients were randomly divided into two groups, exper mental group tor the use of papaverine dilu- ent cure fnr breast cancer improved intraoperative flap hot wet compress and postopera- tive give the Anisodamine 20rag in 100ml 0. 9% Soditlm Chlorideintravenous infusion, the control group tor treatment in the usual way, were observed incision flap healing. Results ：The postoperative of the experimental group of 51 cases of skin flap necrosis in 2 cases, accounting for 3. 92%, control group 48 cases of postoperative flap necrosis in seven cases, accounting for 14. 58% , difference between the two was statistically significant（ P 〈 0.05 ）. Conclusions： papav-erine combined with anisodamine were effective in preventing modified rhdical breast cancer mastectomy flap necrosis.