期刊文献+

α-硫辛酸在糖尿病眼肌麻痹中的应用价值

下载PDF
导出
摘要 目的:观察α-硫辛酸对糖尿病眼球运动神经麻痹的疗效。方法:收治糖尿病眼球运动神经麻痹患者52例(52眼),采用随机法分为对照组26例(26眼)和治疗组26例(26眼),在原有常规治疗并改善微循环治疗基础上,治疗组给予α-硫辛酸肌肉注射,1次/日,14天后进行两组眼位、眼球运动、复视像检查及血清氧化应激指标检测。结果:治疗组与对照组的综合有效率分别为88.46%、61.54%(P<0.05),显效率分别为46.15%,11.54%(P<0.01)。治疗后超氧化物歧化酶(SOD)水平升高,丙二醛(MDA)水平降低。结论:α-硫辛酸对糖尿病眼肌麻痹有明显的治疗作用。
出处 《中国社区医师(医学专业)》 2012年第26期52-53,共2页
  • 相关文献

参考文献5

二级参考文献37

  • 1龚小花,郑景晨.氧化应激与糖尿病神经病变[J].国际内分泌代谢杂志,2006,26(B04):16-18. 被引量:37
  • 2Brownlee M.Biochemistry and molecular cell biology of diabetic complications.Nature,2001,414:813-820.
  • 3Vincent AM,Mclean LL,Backus C,et al.Shorterm hyperglycemia produces oxdative damage and apoptosis in neurons.FASEB J,2005,19:638-640.
  • 4Baydas G,Donder E,Kiliboz M,et al.Neuroprotection by α-lipoic acid in streptozotocin-induced diabetes.Biochemistry,2004,69:1001-1005.
  • 5Klatt P,Esterbauer H.Oxidative hypothesis of artherogenesis[J].J Cardiovasc Risk,1996;3(4):346-51.
  • 6Ziegler D,Schatz H,Conrad F,et al.Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients.A4-month randomized controlled multicenter trial (DEKAN Study).Deutsche Kardiale Autonome Neuropathie[J].Diabetes Care,1997;20(3):369-73.
  • 7Melhem MF,Craven PA,Derubertis FR.Effects of dietary supplementation of a-lipoic acid on early glomerular injury in diabetes mellitus[J].J Am Soc Nephrol,2001;12(1):124-33.
  • 8Sola S,Mir MQ,Cheema FA,et al.Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome:results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study[J].Circulation,2005;111(3):343-8.
  • 9Evans JL,Goldfine ID,Maddux BA,et al.Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction[J] ?Diabetes,2003;52(1):1-8.
  • 10Balkis BS,Othman F,Louis SR,et al.Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats[J].Rom Morphol Embryol,2009;50(1):23-30.

共引文献257

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部