思密达预防红霉素所致胃肠道不良反应的临床观察

目的:探讨思密达预防红霉素所致胃肠道不良反应的临床疗效。方法:应用红霉素静滴治疗患儿86例,随机分成对照组和观察组,每组43例。对照组患儿应用红霉素剂治疗相关疾病。观察组在对照组的基础上加用思密达,静滴红霉素前30分钟温水冲服,剂量<3岁为1.5g,>3岁为3.0g。结果:观察组43例患儿中有5例患儿出现胃肠道反应,其中轻度胃肠道反应4例,严重者1例,胃肠道反应发生率为11.6%;对照组43例患儿有40例发生胃肠道反应,其中轻度11例(25.6%),严重胃肠道反应29例(67.4%),胃肠道反应发生率为93.0%,两组比较差异有显著性。结论:思密达可以预防红霉素所致胃肠道不良反应,减轻患儿的痛苦。

Objective：To investigate the dioetahedral up to prevent the clinical efficacy of erythromycin - induced gastrointestinal side effects. Methods ：The hospital were collected in January 2010 April 2012 pediatric intravenuus erythromyein in children with 86 eases, were randomly divided into control group and observation group, 43 cases of treatmentrelated control group in children with erythrumycin agent diseases. The observatinn gruup on Ihe basis of the control group Smecta warm water 30 minutes before intravenous infusion of erythromycin dose 〈 3 year 1.5g,3 year old 3.0g. Results：43 patients in the observation group, five cases of children with gastrnintestinal reactions, including fbur cases of mild gastrointestinal reaction, one cases of severe cases, gastrointestinal reactions was 11.6% ; control group,43 patients children,40 cases of gastrointestinal reactions, mild 11 cases （25.6%） , severe gastrointestinal reactions 29 cases, accounting for 67.4% , gastrointestinal reaction rate was 93.0% respectively,there were significant differences. Conclusion：smecta the erythromyein induced gastrointestinal side effects can be prevented, to alleviate the suffering of children.