早期肠内营养对重型脑损伤后血清IL-10含量的影响

Influence of early enternal nutrition on serum level of IL-10 in patients with severe brain injury

目的观察重型颅脑损伤后患者血清IL-10的含量变化以及早期肠内营养对IL-10含量的影响。方法 126例重型颅脑损伤患者随机分为肠内营养组(EN组)和肠外营养组(PN组),两组均于伤后第2、3、7和10天采用ELISA法测定血清中IL-10含量。结果两组患者IL-10含量均高于对照组(P<0.01),EN组患者IL-10含量在伤后第3、7和10天低于PN组(P<0.05),而在伤后第1天差异无统计学意义(P>0.05)。结论早期肠内营养支持治疗能够降低重型颅脑损伤患者血清IL-10含量。

Objective To oberative the content change of IL-10 in serum in patients with severe trau- matic brain injury and the influence of early enterual nutrition on serum level of IL-10. Methods 126 patients were divided into EN group and PN Group randomly. ELISA was used to measure serum level of IL-10 in two groups at 1,3,7 and 10 clays after injury. Results The level of serum IL-10 in EN group and PN group was higher than that of the control group（P 〈 0. 01 ）. The level of serum IL-10 in EN group was lower than that in PN group at 3,7 and 10 days after injury（P 〈0. 01 ）, but with insignificant difference at 1 day after injury（P 〉 0. 05 ）. Conclusion Early enternal nutrition can decrease the level of serum IL-10 in patients with severe trau- matic brain iniury.