利福平注射液经纤维支气管镜治疗支气管结核疗效观察

The treatment efficacy of Rifampicin injection by bronchoscopy from patients with bronchial tuberculosis

目的探讨常规全身抗结核治疗联合利福平经纤支镜注射介入治疗支气管结核的疗效。方法对80例支气管结核分别行纤维支气管镜注入利福平注射液,异烟肼+阿米卡星,单纯口服抗结核药物3组治疗结果进行对比分析。结果经纤支镜注射利福平介入治疗支气管结核,较纤维支气管镜注入异烟肼+阿米卡星和单纯口服抗结核药物有显著差异。结论通过纤维支气管镜于病灶处注入利福平注射液治疗支气管结核起效快、效果佳、不良反应少,对减少支气管狭窄、肺不张、毁损肺的发生,提高患者的生存质量有积极的意义。

Objective The aim of this study was to investigate the treatment efficacy of conventional systemic anti-tuberculosis therapy with rifampicin and combine with interventional treatment of rifampicin injec- tion by bronchoscopy from patients with bronchial tuberculosis. Methods Comparative analysis of three group about injection of rifampicin, isoniazid, amikacin respectively by bronchoscopy and Simple oral anti-TB drugs from patients with bronchial tuberculosis （n = 80） Results Interventional treatment of rifampicin injection by bronchoscopy was found significantly more frequently in patients with bronchial tuberculosis than isoniazid, ami- kacin and simple oral anti-TB drugs. Conclusion Using bronchoscope, rifampicin can be directly inject into lesions of bronchial tuberculosis. It was rapid onset, good effect, less adverse reactions and can be reduce bron- chial stenosis, atelectasis and the incidence of lung damage and maybe a positive meaning to improve the quality of life of patients with tuberculosis