参草通脉颗粒丹参酮ⅡA提取工艺研究

Study on extract process of tanshinone A in Salvia miltiorrhiza Bge

目的参草通脉颗粒在临床中治疗慢性心衰疗效确切,有效率达到90%以上,为了进一步明确中药的疗效成分便于推广研究。我们探讨其主要药物丹参中丹参酮ⅡA的最佳醇提取工艺条件,为丹参药材的综合利用提供实验依据。方法采用正交试验法,以丹参酮ⅡA的提取量及浸膏得率为考察指标,优选回流法提取的最佳工艺条件。结果最佳提取工艺为:以10倍量80%乙醇回流提取3次,每次1h。结论优选的提取工艺设计合理,丹参酮ⅡA提取率较高。

Objective To develop comprehensive utilization of Salvia miltiorrhiza to explore the best conditions of extract Tanshinone A in Salvia miltiorrhiza Bge by ethanol. Methods With tanshinone A and Yield of extract as index, optimization of reflux to the optimum conditions. Results The optimal refluxing was to extract ten times with 80% alcohol. Conclusion Optimization extraction process design is reasonable, ex- traction rate of Tanshinone is higher.