注射用头孢派酮钠舒巴坦钠治疗外科急腹症临床疗效观察

The injectable cephalosporin send ketone sulbactam Clinical observation on the treatment of acute surgical abdomen

目的比较头孢哌酮钠舒巴坦钠与头孢噻肟钠治疗外科急腹症中度感染的疗效性与安全性。方法外科急腹症病例109例,随机对照治疗,分为两组,其中头孢哌酮纳舒巴坦钠与头孢噻肟钠组分别为:55与54例,两组剂量均为4g/d、bid静脉滴注,疗程为5～10d。结果头孢哌酮钠舒巴坦钠与头孢噻肟钠的临床有效率为:90.91%和79.63%,细菌清除率分别为:88.24%和72.34%,头孢哌酮钠舒巴坦钠明显优于头孢噻肟钠,不良反应发生率分别为:5.45%和5.56%,无统计学显著差异。结论头孢哌酮钠舒巴坦钠治疗外科急腹症中度感染是一个安全有效的抗菌药物。

Objective To compare the efficacy and safety of surgical abdomen moderate infections with cefoperazone sulbactam and cefotaxime sodium. Methods 109 cases of cases of acute surgical abdomen, ran- domized controlled treatment were divided into two groups, which of sodium cefoperazone Nashubatan cefotaxime sodium, respectively： 55 and 54 cases, and the two groups are 4 g / d dose twice dailyintravenous infusion, treatment for 5 - 10 d. Results Cefoperazone sulbactam and cefotaxime sodium clinical effective rate： 90. 91% and 79.63%, bacterial clearance rates were as follows： 88.24% and 72. 34%, cefoperazone sulbac- tam significantly superior to cefotaxime sodium, adverse reactionrate： 5.45 % and 5.56%, respectively, and no statistically significant differences. Conclusion Cefoperazone sulbactam treatment surgical acute abdomen moderate infection is a safe and effective antimicrobial agents.