层粘连蛋白-111在血管生成中作用的研究进展

Research progress of laminin-111 in angiogensis

层粘连蛋白是细胞外基质中的一种非胶原性糖蛋白，至今已发现有15种亚型。但是各亚型间功能有所差别，主要在体内参与细胞黏附、转移、分化、生长，以及信号转导、组织修复。而且层粘连蛋白在血管生成中也具有重要作用。本文旨在对层粘连蛋白亚型-111在血管生成中的作用及研究现状作一综述。

Laiminin, which has been found 15 isoforms up to today, is a kind of noneollagen glycoprotein of extracellular matrix. However, the functions of laminin vans from each other, which mainly takes participation in the process of the cell adherence, migration, differentiation, growth, cell signaling and tissue repair in vivo. In recent years, some scholars have found that laminin plays an important role in angiogenesis. The purpose of this article is to summarize the role of laminin in angiogensis and sum up the current research progress.