摘要
胆囊癌是胆道系统最常见的恶性肿瘤，其早期诊断率低，患者预后极差。目前关于胆囊癌的发病机制尚未阐明。近年来，关于肿瘤干细胞研究的不断深入，在胆囊癌中，最新的研究证实胆囊癌GBC．SD细胞系中分离出了SP细胞。同时，胆囊癌中存在CD133^＋细胞、CD44^＋细胞、CD133^＋CD44^＋细胞，并具有克隆形成能力、增生能力、分化能力及成瘤能力。本文就以胆囊癌与肿瘤干细胞关系的研究进展进行综述。
Gallbladder carcinoma is the most common malignant tumor in biliary system, the early diagnosis rate is still very low and the prognosis is extremely poor. At present, the pathogenesis of gallbladder is not clear. Recently, with the development of the neoplastic stem cell research on gallbladder carcinoma, the latest study showed SP positive cells could be separated from the GBC-SD cell. Further more, related researches have shown that gallbladder respectively with CD133^＋ cells, CD44^＋ cells, CD133^＋ CD44^＋ cells had possessed the cloned formation ability, the stronger growth ability, the differentiation capacity and forming-tumor ability. In this review, we will discuss the research of the relationship between the gallbladder carcinoma and neoplastic stem cells.
出处
《国际外科学杂志》
2012年第9期615-618,共4页
International Journal of Surgery
基金
国家自然科学基金资助项目，上海市教委基金资助项目
