胰岛素泵与多次皮下注射强化治疗Ⅱ型糖尿病的疗效对比分析

Continuous subcutaneous insulin infusion for treatment of type Ⅱ diabetes mellitus

目的对比持续胰岛素泵强化皮下输注(CSII)和胰岛素多点皮下注射(MDI)在Ⅱ型糖尿病患者强化治疗中的效果。方法 100例Ⅱ型糖尿病患者随机分为CSII和MDI两组,每组各50例,CSII组使用持续胰岛素皮下输注赖脯胰岛素(Lispro Injection)强化治疗;MDI组使用赖脯胰岛素联合精蛋白锌重组人胰岛素中效型(Humulin NPH)多点皮下注射强化治疗,对比分析两组血糖改善情况。结果 CSII组比MDI组控制血糖更理想,血糖波动更小,达标更快,低血糖发生率更低,单位体重胰岛素用量更少,差异均有统计学意义(P<0.05)。结论 CSII能更好、更快、更安全地完成Ⅱ型糖尿病的强化治疗,可在临床治疗中推广应用。

Objective To compare the effects of continuous subcutaneous insulin infusion（CSII）and multiple daily injections（MDI）as intensive insulin therapy for patients with type Ⅱ diabetes mellitus.Methods 100 patients with type Ⅱdiabetes mellitus were divided into randomly receive continuous subcutaneous lipro insulin injection group（n=50）or multiple daily injection with lipro insulin and humulin NPH group（n=50）.Results Group CSII reached blood glucose targets faster than group MDI.Less fluctuation of blood glucose and hypoglycemia was found in group CSII.Patients in group CSII needed less dosage of insulin per body weight.Conclusion Continuous subcutaneous insulin infusion is a better,faster and safer intensive therapy for type Ⅱ diabetes mellitus.